A SMALL PEPTIDE TARGETING THE LIGAND-INDUCED ANDROGEN RECEPTOR/FILAMIN A INTERACTION INHIBITS THE INVASIVE PHENOTYPE OF PROSTATE CANCER CELLS

A Small Peptide Targeting the Ligand-Induced Androgen Receptor/Filamin a Interaction Inhibits the Invasive Phenotype of Prostate Cancer Cells

Prostate cancer (PC) is one of the most widespread malignancies among males worldwide.The androgen receptor (AR) plays a major role in prostate cancer development and progression and is the main target of PC therapy.Nonetheless, its action is not yet fully elucidated.We report here that the AR associates with Filamin A (FlnA) promoting migration an

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The Future of Labour Justice in the Czech Republic

The paper is focused on the general prerequisites of good judiciary.Specifically, the author points out the current problems and shortcomings of the Czech judiciary, such as the length of proceedings, inconsistency in decision-making, and insufficient erudition.He then discusses individual conditions, possibilities and measures that could be used t

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A Multi-Depot Dynamic Vehicle Routing Problem with Stochastic Road Capacity: An MDP Model and Dynamic Policy for Post-Decision State Rollout Algorithm in Reinforcement Learning

In the event of a disaster, the road network is often compromised in terms of its capacity and usability conditions.This is a challenge for humanitarian operations in the context Kids Footwear of delivering critical medical supplies.To optimise vehicle routing for such a problem, a Multi-Depot Dynamic Vehicle-Routing Problem with Stochastic Road Ca

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